Stability of DNA-Methylation Profiles of Biological Aging in Children and Adolescents.

Abby J deSteiguer Laurel A Raffington Aditi Sabhlok Peter T Tanksley Elliot M Tucker-Drob Kathryn Paige Harden

Published in: bioRxiv : the preprint server for biology (2023)

Children's methylation profiles of biological aging are moderately stable across an approximately four-year period. Methylation profiles are less stable in childhood than in adulthood, suggesting that aging-related biology in childhood might be more responsive to environmental changes than in adulthood.

Keyphrases

dna methylation
early life
genome wide
depressive symptoms
gene expression
young adults
childhood cancer
cancer therapy
risk assessment
life cycle