Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use.
Hannah A WangHua-Jun LiangThomas M ErnstKenichi OishiLinda ChangPublished in: Journal of neuroinflammation (2020)
Our findings suggest that, except in the globus pallidus, chronic MJ use had no additional negative influence on brain microstructure or neurocognitive deficits in HIV+ individuals. However, lower AD in the uncinate fasciculus of MJ users suggests axonal loss in this white matter tract that connects to cannabinoid receptor rich brain regions that are involved in verbal memory and emotion. Furthermore, the greater than normal age-dependent FA declines in the white matter tracts and globus pallidus in MJ users suggest that older chronic MJ users may eventually have lesser neuronal integrity in these brain regions.
Keyphrases
- white matter
- multiple sclerosis
- deep brain stimulation
- antiretroviral therapy
- hiv positive
- human immunodeficiency virus
- hepatitis c virus
- hiv testing
- working memory
- traumatic brain injury
- hiv aids
- depressive symptoms
- spinal cord injury
- bipolar disorder
- physical activity
- resting state
- cerebral ischemia
- brain injury
- subarachnoid hemorrhage
- middle aged
- optic nerve