Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux.
Rui ChenYao XuWei ZhongBo LiPing YangZhong Qun WangChen ShaoCui Ping WangJin Chuan YanPublished in: Mediators of inflammation (2018)
The present study identified a new pathway in which CD137 promotes VSMC calcification through the activation of JNK signaling, subsequently leading to the disruption of autophagic flux, which is responsible for CD137-induced acceleration of vascular calcification.