Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition.
Xiangdong WangChristopher J WalkeyAna C Maretti-MiraLei WangDeborah L JohnsonLaurie D DeLevePublished in: Hepatology (Baltimore, Md.) (2020)
Lack of signaling to recruit BM sprocs that repair injured LSECs renders steatotic liver more susceptible to I/R injury. Liver-selective MMP-9 inhibition enhances VEGF-sdf1 signaling and recruitment of BM sprocs, which markedly protects against I/R injury, even in severely steatotic rats.
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