PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2.

Yuming WangYiwei LiuHairong ChenZhenggang XuWangjie JiangXiao XuJijun ShanJiang ChangTao ZhouJifei WangAnlan ChenyanShilong FanZifan TaoKe ShaoXiangcheng LiXiaofeng ChenGuwei JiXiaofeng Wu

Published in: Cellular oncology (Dordrecht, Netherlands) (2024)

Overall, our study emphasizes the critical role of the PIN1/RACK1/ANXA2 complex in CCA growth and functionality, highlighting the potential of targeting PIN1 as a promising therapeutic strategy for CCA.

Keyphrases

induced apoptosis
cell cycle arrest
cancer therapy
endoplasmic reticulum stress
signaling pathway
risk assessment
human health
climate change