Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits.

Yaxi LiZeshun LiDehong HuShuxian WangMenglei ZhaSong-Bo Lu Zonghai Sheng Kai Li

Published in: Chemical communications (Cambridge, England) (2021)

The functional NIR-II emissive nanoprobe loaded with AIEgen (cRGD-TTB NPs) achieved a high quantum yield (10.32%) and a high signal-to-background (S/B) ratio of 7.7 when employed for the visualization of large tumors (∼600 mm3) in rabbit models for the first time. This work will aid in the investigation of tumor targeting effect of therapeutic agents in large animal models.

Keyphrases

cancer therapy
fluorescence imaging
photodynamic therapy
drug delivery
drug release
fluorescent probe
molecular dynamics
living cells
adipose tissue
energy transfer
electron microscopy