Potent and Non-Cytotoxic Antibacterial Compounds Against Methicillin-Resistant Staphylococcus aureus Isolated from Psiloxylon mauritianum, A Medicinal Plant from Reunion Island.
Jonathan SorresAmandine AndréElsa Van ElslandeDidier StienVéronique EparvierPublished in: Molecules (Basel, Switzerland) (2020)
With the occurrence of antibiotic-resistant Staphylococcus aureus strains, identification of new anti-staphylococcal drugs has become a necessity. It has long been demonstrated that plants are a large and diverse source of antibacterial compounds. Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, was chemically investigated for its reported biological activity against S. aureus. Aspidin VB, a phloroglucinol derivative never before described, together with Aspidin BB, were first isolated from the ethyl acetate extract of P. mauritianum leaves. Their structures were elucidated from spectroscopic data. Aspidin VB exhibited strong antibacterial activity against standard and methicillin-resistant S. aureus strains, with a minimal inhibition concentration (MIC) of 0.25 μg/mL, and no cytotoxicity was observed at 10-5 M in MRC5 cells. Due to its biological activities, Aspidin VB appears to be a good natural lead in the fight against S. aureus.
Keyphrases
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- silver nanoparticles
- anti inflammatory
- escherichia coli
- induced apoptosis
- essential oil
- biofilm formation
- cell cycle arrest
- oxidative stress
- molecular docking
- risk assessment
- electronic health record
- high resolution
- signaling pathway
- cell wall
- big data
- bioinformatics analysis
- mass spectrometry
- wound healing
- deep learning
- cell death
- drug induced
- machine learning