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Dying to protect: cell death and the control of T-cell homeostasis.

Kun-Po LiSharmila ShanmuganadKaitlin CarrollJonathan D KatzMichael B JordanDavid A Hildeman
Published in: Immunological reviews (2018)
T cells play a critical role in immune responses as they specifically recognize peptide/MHC complexes with their T-cell receptors and initiate adaptive immune responses. While T cells are critical for performing appropriate effector functions and maintaining immune memory, they also can cause autoimmunity or neoplasia if misdirected or dysregulated. Thus, T cells must be tightly regulated from their development onward. Maintenance of appropriate T-cell homeostasis is essential to promote protective immunity and limit autoimmunity and neoplasia. This review will focus on the role of cell death in maintenance of T-cell homeostasis and outline novel therapeutic strategies tailored to manipulate cell death to limit T-cell survival (eg, autoimmunity and transplantation) or enhance T-cell survival (eg, vaccination and immune deficiency).
Keyphrases
  • cell death
  • immune response
  • cell cycle arrest
  • high grade
  • dendritic cells
  • celiac disease
  • palliative care
  • working memory
  • smoking cessation
  • signaling pathway
  • type iii