Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responses.
Jon Petur JoelssonJennifer A KrickerAri J ArasonSnaevar SigurdssonBryndis ValdimarsdottirFridrik Runar GardarssonClive P PageFredrik LehmannThorarinn GudjonssonSaevar IngthorssonPublished in: Respiratory research (2020)
Using a mouse model of AE barrier dysfunction we provide evidence for the protective effects of AZM in vivo, possibly through stabilizing the intracellular microenvironment and reducing inflammatory responses. Our data provide insight into the mechanisms contributing to the efficacy of AZM in the treatment of airway diseases.