Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responses.

Jon Petur JoelssonJennifer A KrickerAri J ArasonSnaevar SigurdssonBryndis ValdimarsdottirFridrik Runar GardarssonClive P PageFredrik LehmannThorarinn GudjonssonSaevar Ingthorsson

Published in: Respiratory research (2020)

Using a mouse model of AE barrier dysfunction we provide evidence for the protective effects of AZM in vivo, possibly through stabilizing the intracellular microenvironment and reducing inflammatory responses. Our data provide insight into the mechanisms contributing to the efficacy of AZM in the treatment of airway diseases.

Keyphrases

mouse model
oxidative stress
stem cells
electronic health record
big data
reactive oxygen species
drug induced
combination therapy
data analysis
artificial intelligence
stress induced