Narrative review of the effects of antidiabetic drugs on albuminuria.
Habib YaribeygiStephen L AtkinNiki KatsikiAmir Hossein SahebkarPublished in: Journal of cellular physiology (2018)
Diabetes mellitus is the most prevalent metabolic disorder worldwide. Glycemic control is the main focus of antidiabetic therapy. However, there are data suggesting that some antidiabetic drugs may have intrinsic beneficial renal effects and protect against the development and progression of albuminuria, thus minimizing the risk of diabetic nephropathy. These pharmacological agents can suppress upstream molecular pathways involved in the pathophysiology of diabetes-induced renal dysfunction such as oxidative stress, inflammatory responses, and apoptosis. In this narrative review, the pathophysiology of albuminuria in patients with diabetic nephropathy is discussed. Furthermore, the renoprotective effects of antidiabetic drugs, focusing on albuminuria, are reviewed.
Keyphrases
- diabetic nephropathy
- glycemic control
- oxidative stress
- type diabetes
- diabetic rats
- blood glucose
- weight loss
- drug induced
- dna damage
- cardiovascular disease
- insulin resistance
- high glucose
- ischemia reperfusion injury
- induced apoptosis
- cell cycle arrest
- electronic health record
- big data
- endothelial cells
- machine learning
- single molecule
- cell proliferation
- data analysis