Oxidative Mannich Reactions of Tertiary Amines Using a Cu(II) 2-Quinoxalinol Salen Catalyst.

Oxidative Mannich reactions can be catalyzed using a Cu(II) 2-quinoxalinol salen catalyst and with tert-butyl hydroperoxide (TBHP). Under mild conditions, a range of both cyclic and open chain tertiary amines was tested as substrates, resulting in yields up to 98%.