Higher IGFBP3 is associated with increased incidence of colorectal cancer in older men independently of IGF1.

Yi X ChanHelman AlfonsoStephen Anthony Paul ChubbKen K Y HoPeter Gerard FeganGraeme J HankeyJonathan GolledgeLeon FlickerBu B Yeap

Published in: Clinical endocrinology (2017)

Higher IGFBP3 predicted increased incidence of colorectal cancer in older men independent of conventional risk factors and total IGF1. Further studies are warranted to explore potential underlying mechanisms.

Keyphrases

risk factors
middle aged
community dwelling
physical activity
pi k akt
binding protein
growth hormone
signaling pathway