Concurrent RB1 Loss and BRCA-Deficiency Predicts Enhanced Immunological Response and Long-Term Survival in Tubo-Ovarian High-Grade Serous Carcinoma.
Flurina Anna-Carina Maria SanerKazuaki TakahashiTimothy BuddenAhwan PandeyDinuka AriyaratneTibor Andrea ZwimpferNicola S MeagherSian FeredayLaura TwomeyKathleen I PishasTherese HoangAdelyn BolithonNadia TraficanteKathryn AlsopElizabeth L ChristieEun-Young KangGregg S NelsonPrafull GhatageCheng-Han LeeMarjorie J RigganJennifer AlsopMatthias W BeckmannJessica BorosAlison H BrandAngela R Brooks-WilsonMichael E CarneyPenny CoulsonMadeleine Courtney-BrooksKara L Cushing-HaugenCezary CybulskiMona A El-BahrawyEsther ElishaevRamona ErberSimon A GaytherAleksandra Gentry-MaharajC Blake GilksPaul R HarnettHolly R HarrisArndt HartmannAlexander HeinJoy HendleyBrenda Y HernandezAnna JakubowskaMercedes Jimenez-LinanMichael E JonesScott H KaufmannCatherine J KennedyTomasz KluzJennifer M KoziakBjörg KristjansdottirNhu D LeMarcin R LenerJenny LesterJan A LubińskiConstantina MateoiuSandra OrsulicMatthias RuebnerMinouk J SchoemakerMitul ShahRaghwa SharmaMark E ShermanYurii B ShvetsovThing Rinda SoongHelen SteedPaniti SukumvanichAline TalhoukSarah E TaylorRobert A VierkantChen WangMartin WidschwendterLynne R WilkensStacey J WinhamMichael S AnglesioAndrew BerchuckJames D BrentonIan G CampbellLinda S CookJennifer Anne DohertyPeter Andreas FaschingRenée Turzanski FortnerMarc T GoodmanJacek GronwaldDavid G HuntsmanBeth Y KarlanLinda E KelemenUsha MenonFrancesmary ModugnoPaul David Peter PharoahJoellen M SchildkrautKarin SundfeltAnthony J SwerdlowEllen L GoodeAnna De FazioMartin KoebelSusan J RamusDavid D L BowtellDale W GarsedPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Co-occurrence of RB1 loss and BRCA-deficiency was associated with exceptionally long survival in patients with HGSC, potentially due to better treatment response and immune stimulation.