Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation.
Harlie A CopeBevin E BlakeCharlotte A LoveJames P McCordSusan A ElmoreJanice B HarveyVesna A ChappellSuzanne E FentonPublished in: Emerging contaminants (2021)
Prenatal exposure to 1 mg/kg GenX and 1 mg/kg PFOA induces adverse metabolic outcomes in adult mice that are diet- and sex-dependent. GenX also accumulated in pup serum, suggesting that placental and potentially lactational transfer are important exposure routes for GenX.