Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy.
Salah DajaniVirginia B HillJohn A KalapurakalCraig M HorbinskiEric G NesbitSean SachdevAmulya YalamanchiliTarita O ThomasPublished in: Journal of clinical medicine (2022)
Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as well as the diagnostic imaging characteristics of this tumor. In addition, factors that affect prognosis such as differentiating progression from treatment effect is discussed. The role of MRI guided radiation therapy and how this technology may provide a mechanism to improve the care of patients with this disease are described.
Keyphrases
- radiation therapy
- contrast enhanced
- high resolution
- magnetic resonance imaging
- healthcare
- palliative care
- locally advanced
- stem cells
- computed tomography
- magnetic resonance
- diffusion weighted imaging
- combination therapy
- squamous cell carcinoma
- quality improvement
- mesenchymal stem cells
- chronic pain
- photodynamic therapy
- pain management
- replacement therapy
- single molecule
- smoking cessation