FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer.
Marta CanelAleksandra Dominika SławińskaDavid W LonerganAshwin Adrian KallorRosanna Upstill-GoddardCatherine DavidsonAlex von KriegsheimAndrew V BiankinAdam ByronJavier AlfaroAlan SerrelsPublished in: Gut (2023)
Therapies aimed at FAK degradation may unlock additional therapeutic benefit for the treatment of PDAC through increasing antigen diversity and promoting antigen presentation.