Local effect of simvastatin combined with different osteoconductive biomaterials and collagen sponge on new bone formation in critical defects in rat calvaria.
Dircilei Nascimento de SousaVirgílio Moreira RorizGuilherme Jose Pimentel Lopes de OliveiraWagner Rodrigues DuarteLeonardo Nogueira de Miranda Pereira PintoLeonora Maciel de Souza ViannaFabiana Pirani CarneiroVania Maria Moraes FerreiraPublished in: Acta cirurgica brasileira (2020)
The use of SVT without the need for a vehicle and combined with a commercially available biomaterial may be a cheaper way to potentiate the formation of bone tissue without the need to produce new biomaterials. Therefore, SVT combined with DBB induced significantly greater new bone formation than did the other treatments.