Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner.

Borna SarkerSandra M CardonaKaira A ChurchDifernando VanegasPriscila VelazquezColin RorexDerek RodriguezAndrew S MendiolaTimothy S KernNadia D DomingoRobin StephensIsabel A MuzzioAstrid E Cardona

Published in: ASN neuro (2022)

Diabetic human and murine retinas revealed pronounced microglial morphological activation and vascular abnormalities associated with inflammation. Pharmacological fibrinogen depletion using ancrod dampened microglial morphology alterations, resolved fibrinogen accumulation, rescued axonal integrity, and reduced inflammation in the diabetic murine retina.

Keyphrases

oxidative stress
type diabetes
inflammatory response
endothelial cells
diabetic retinopathy
optic nerve
lipopolysaccharide induced
wound healing
spinal cord injury
lps induced
optical coherence tomography
single cell
mouse model
spinal cord
peripheral nerve