One-Pot Synthesis of 3-Methyl-2-arylimidazo[1,2- a ]pyridines Using Calcium Carbide as an Alkyne Source.

An efficient method for the construction of 3-methyl-2-arylimidazo[1,2- a ]pyridines from the reactions of calcium carbide, 2-aminopyridines, and aromatic aldehydes is described. The notable advantages for this strategy include the use of an inexpensive and concise solid alkyne source, cheap and readily available raw materials, wide-scope substrates, and a simple work-up procedure.