Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima.
Peng-Hui XueNan ZhangDa LiuQing-Ran ZhangJing-Shi DuanYa-Qin YuJin-Yan LiShi-Jie CaoFeng ZhaoNing KangFeng QiuPublished in: Journal of natural products (2021)
Sixteen new sesquiterpene lactones (1-16) along with 13 known analogues (17-29) were isolated from the whole plants of Centipeda minima. The structures of 1-16 were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23-26 showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC50 values of 0.8-2.6, 0.4-3.3, and 1.1-2.6 μM, respectively. Compounds 8, 15, and 24 exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC50 values ranging from 0.1 to 0.2 μM.
Keyphrases
- anti inflammatory
- high resolution
- nitric oxide
- molecular docking
- cell cycle arrest
- solid state
- magnetic resonance
- adipose tissue
- toll like receptor
- inflammatory response
- electron microscopy
- nitric oxide synthase
- lps induced
- hydrogen peroxide
- density functional theory
- molecular dynamics simulations
- mass spectrometry
- crystal structure
- cell death
- dual energy