Cutaneous toxicity of FDA-approved small-molecule kinase inhibitors.

Jiangxia DuHao YanJiangxin XuBo YangQiaojun HeXiaohong WangPeihua Luo

Published in: Expert opinion on drug metabolism & toxicology (2021)

It is significant to determine the risk factors for SMKI-induced cutaneous toxicity. The mechanisms underlying SMKI-induced cutaneous toxicities remain unclear at present. Future research should focus on the mechanisms of SMKI-induced cutaneous toxicities to find out mechanistically driven therapies.

Keyphrases

small molecule
high glucose
diabetic rats
oxidative stress
drug induced