Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway.

Yimeng ZhangXufeng TaoLianhong YinLina XuYouwei XuYan QiXu HanShasha SongYanyan ZhaoYuan LinKexin LiuJinyong Peng

Published in: British journal of pharmacology (2017)

Our results have linked CDDP-induced nephrotoxicity and the miR-34a/Sirt1 signalling pathway, which was modulated by dioscin. This natural product could be developed as a new candidate to alleviate CDDP-induced renal injury.

Keyphrases

drug induced
high glucose
diabetic rats
cell proliferation
long non coding rna
endothelial cells
ischemia reperfusion injury