Selective vulnerability to atrophy in sporadic Creutzfeldt-Jakob disease.

Kyan Younes Julio C RojasAmy WolfGoh M Sheng-YangMatteo Paoletti Gianina Toller Eduardo Caverzasi Maria Luisa Mandelli Ignacio Illán-Gala Joel H Kramer Yann Cobigo Bruce L Miller Howard J Rosen Michael D Geschwind

Published in: Annals of clinical and translational neurology (2021)

Brain atrophy in sCJD preferentially affects specific cortical and subcortical regions, with an effective connectivity model showing strength and directionality between regions. Brain atrophy is present in Fast- and Slow-progressors, correlates with clinical findings, and is a potential biomarker in sCJD.

Keyphrases

white matter
resting state
functional connectivity
multiple sclerosis
climate change
late onset
blood brain barrier