Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade.
Michael L DixonLin LuoSadashib GhoshJeffrey M GrimesJonathan D LeavenworthJianmei Wu LeavenworthPublished in: Molecular cancer (2021)
These findings revealed Blimp1 as a new critical regulator of tumor-infiltrating Treg cells and a potential target for modulating Treg activity to treat cancer. Our study has also revealed two FCERIA-containing immune signatures as promising diagnostic or prognostic markers for melanoma patients.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- induced apoptosis
- single cell
- papillary thyroid
- peritoneal dialysis
- signaling pathway
- prognostic factors
- dendritic cells
- cell cycle arrest
- squamous cell
- genome wide
- patient reported outcomes
- dna methylation
- gene expression
- young adults
- climate change
- human health
- lymph node metastasis