Association between FGFR1 copy numbers, MAP3K1 mutations, and survival in axillary node-positive, hormone receptor-positive, and HER2-negative early breast cancer in the PACS04 and METABRIC studies.
Dimitri CareneAlicia Tran-DienJérôme LemonnierFlorence DalencChristelle LevyJean-Yves PiergaWilliam JacotJean-Luc CanonCatherine RichonLudovic LacroixChristophe CauxFabrice AndréStefan MichielsPublished in: Breast cancer research and treatment (2019)
In axillary node-positive, HR+, and HER2- early BC, amplifications of FGFR1 gene were strongly associated with increased risk for distant disease, while mutations of MAP3K1 gene were significantly associated with decreased risk.