Clinical severity of enteric viruses detected using a quantitative molecular assay compared to conventional assays in the Global Enteric Multicenter Study.
Jordan E CatesHelen PowellJames Platts-MillsDilruba NasrinSandra PanchalingamSamba O SowAwa TraoreDipika SurThandavarayan RamamurthyAnita K M ZaidiFurqan KabirAbu S G FaruqueDilruba AhmedRobert F BreimanRichard OmoreJohn Benjamin OchiengM Jahangir HossainMartin AntonioInácio MandomandoDelfino VubilJames P NataroMyron M LevineUmesh D ParasharKaren L KotloffJacqueline E TatePublished in: The Journal of infectious diseases (2024)
Quantitative molecular assays compared to conventional assays, such as EIA, may influence severity of identified cases, especially for rotavirus. Cutoffs to assign etiology for quantitative assays should be considered in the design and interpretation of enteric virus studies.