Paediatric-onset and adult-onset Graves' disease share multiple genetic risk factors.

Aleksander KuśMikołaj RadziszewskiAleksandra GlinaKonrad SzymańskiBeata Jurecka-LubienieckaEdyta Pawlak-AdamskaDorota KulaNatalia Wawrusiewicz-KurylonekJoanna KuśPiotr MiśkiewiczRafał PłoskiMarek BolanowskiJacek DaroszewskiBarbara JarząbArtur BossowskiTomasz Bednarczuk

Published in: Clinical endocrinology (2018)

The results of our study revealed that POGD and AOGD share multiple common genetic risk variants. Moreover, we demonstrated for the first time that HCP5 polymorphism is associated with an earlier age of GD onset in a dose-dependent manner.

Keyphrases

risk factors
copy number
genome wide
intensive care unit
emergency department
dna methylation
gene expression