Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections.
Aleksandr IanevskiRouan YaoEva ZusinaiteLaura Sandra LelloSainan WangEunji JoJaewon YangErlend RavloWei WangHilde LysvandKirsti LøsethValentyn OksenychTanel TensonMarc P WindischAlejandro Reyes MuñozAnni I NieminenSvein Arne NordbøMona Hoysaeter FenstadGunnveig GrødelandPål AukrustMarius TrøseidAnu KanteleEglė LastauskienėAstra VitkauskienėNicolas LegrandAndres MeritsMagnar BjøråsDenis E KainovPublished in: Viruses (2021)
Altogether, our results indicated that IFNα can be combined with drugs that affect viral RNA transcription, protein synthesis, and processing to make synergistic combinations that can be attractive targets for further pre-clinical and clinical development against emerging and re-emerging viral infections.