Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas.
Jordan J WrightJonathan M WilliamsLisa R Letourneau-FreibergBalamurugan KandasamyDemetra ReyesAnastasia L Gant KanegusukuLouis PhilipsonSiri Atma W GreeleyMelissa A HilmesSimeon I TaylorJohn VirostkoDaniel J MoorePublished in: Diabetes care (2023)
These results suggest that severe insulin deficiency, rather than islet-directed autoimmunity, leads to reduced pancreas size in type 1 diabetes and that insulin is a major trophic factor for the exocrine pancreas.