Comparison of ¹⁸F-fluorothymidine Positron Emission Tomography/Computed Tomography and ¹⁸F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Breast Cancer.

The uptake of ¹⁸F-fluorothymidine (¹⁸F-FLT) depends on cells' proliferative rates. We compared the characteristics of ¹⁸F-FLT positron emission tomography/computed tomography (PET/CT) with those of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET/CT for breast cancer. We prospectively diagnosed patients with breast cancer who underwent ¹⁸F-FLT PET/CT and ¹⁸F-FDG PET/CT. Subsequently, significant differences and correlation coefficients of the maximum standardized uptake value (SUVmax) in primary breast cancer and axillary lymph nodes were statistically evaluated. We enrolled eight patients with breast cancer. In six treatment-naive patients, the SUVmax for primary lesions showed a significant difference (mean, 2.1 vs. 4.1, <i>p</i> = 0.031) and a strong correlation (<i>r</i> = 0.969) between ¹⁸F-FLT and ¹⁸F-FDG. Further, although the SUVmax for the axillary lymph nodes did not show a significant difference between ¹⁸F-FLT and ¹⁸F-FDG (P = 0.246), there was a strong correlation between the two (r = 0.999). In a patient-by-patient study, there were cases in which only ¹⁸F-FDG uptake was observed in lymph nodes and normal breasts. Bone metastases demonstrated lower accumulation than bone marrow on the ¹⁸F-FLT PET/CT. In conclusion, a strong correlation was observed between the ¹⁸F-FLT PET/CT and ¹⁸F-FDG PET/CT uptake. Differences in the biochemical characteristics of ¹⁸F-FLT and ¹⁸F-FDG were reflected in the accumulation differences for breast cancer, metastatic lesions, and normal organs.