Evaluating risk for alcohol use disorder: Polygenic risk scores and family history.
Dongbing LaiEmma C JohnsonSarah M C ColbertGayathri PandeyGrace ChanLance O BauerMeredith W FrancisVictor M HesselbrockChella KamarajanJohn R KramerWeipeng KuangSally KuoSamuel KupermanYunlong LiuVivia V McCutcheonZhiping P PangMartin Henry PlaweckiMarc SchuckitJay TischfieldLeah WetherillYong ZangHoward J EdenbergBernice PorjeszArpana AgrawalTatiana ForoudPublished in: Alcoholism, clinical and experimental research (2022)
Both PRS and family history were associated with AUD and AUD severity, indicating that these risk measures assess distinct aspects of liability to AUD traits.