Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways.

Arshi KhanamAlip GhoshJoel V ChuaShyam Kottilil

Published in: Journal of translational medicine (2023)

CCR4 blockade reconstitutes antiviral immune response in T cells and limits the immunosuppressive functions of Tregs, representing them as a promising immunotherapeutic target for functional cure of CHB.

Keyphrases

immune response
end stage renal disease
dendritic cells
ejection fraction
newly diagnosed
peritoneal dialysis
toll like receptor
prognostic factors
patient reported outcomes
inflammatory response
liver fibrosis