Effect of doxycycline on chronic intermittent hypoxia-induced atrial remodeling in rats.

K ZhangZ MaW WangR LiuY ZhangM YuanGuangping Li

Published in: Herz (2018)

CIH induced significant atrial remodeling, which was attenuated by doxycycline in our rat model. These changes can be explained by the alterations initiated in the miR-133a/TGF-β1/CTGF pathway by doxycycline.

Keyphrases

atrial fibrillation
cell proliferation
left atrial
long non coding rna
high glucose
catheter ablation
drug induced
diabetic rats
transforming growth factor
high intensity
heart failure
oxidative stress