Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28.

Shujun ZhangPeilong LiJuan LiJie GaoQiuchen QiGuoying DongXiaoyan LiuQinlian JiaoYunshan WangChuanxin Wang Hanxiang Zhan Shuo Xu Chuanxin Wang

Published in: British journal of cancer (2023)

Our study uncovered that KRAS-driven FOSL2 promoted PDAC progression by transcriptionally activating CCL28, revealing an immunosuppressive role for FOSL2 in PDAC.

Keyphrases

liver fibrosis
wild type
liver injury
gene expression
signaling pathway
dna damage
transcription factor
genome wide