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Rheumatology Common Toxicity Criteria (RCTC): An Update Reflecting Real-World Use.

Christian M StachVictor S SloanThasia G WoodworthBrian KilgallenDaniel E Furst
Published in: Drug safety (2020)
The RCTC 2.0 performed as intended, although some inaccuracies and omissions were found. We provide a corrected version, RCTC 2.1, and also recommend further revision of the RCTC within OMERACT guidances to include AEs that have been reported in rheumatology clinical trials since RCTC 2.0 was published. Ideally, a revised RCTC 3.0 would not only facilitate standardized assessment and reporting of AEs, but would also expand and encourage accurate comparison of the safety profiles of treatments for rheumatic/autoimmune diseases.
Keyphrases
  • clinical trial
  • juvenile idiopathic arthritis
  • oxidative stress
  • emergency department
  • high resolution
  • systematic review
  • adverse drug
  • systemic lupus erythematosus
  • open label
  • clinical evaluation