Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development.

Lubov V KrepkovaValentina V BortnikovaAleksandra N BabenkoPraskovya G MizinaVladimir A MkhitarovKathleen M JobCatherine M SherwinElena Y Enioutina

Published in: BMC complementary medicine and therapies (2021)

PADE treatment of male rates negatively affected sperm and testicular Leydig cell morphology. However, these changes did not affect male fertility and offspring development. It is currently not known whether PADE treatment may affect human male fertility and offspring development. Therefore, these results from an animal study need to be confirmed in humans. Results from this animal study can be used to model the exposure-response relationship and adverse outcomes in humans.

Keyphrases

high fat diet
endothelial cells
single cell
cell therapy
combination therapy
skeletal muscle
bone marrow
young adults
insulin resistance