Infrared Fluorescence-guided Surgery for Tumor and Metastatic Lymph Node Detection in Head and Neck Cancer.
Haley W WhiteAbdullah Bin NaveedBenjamin R CampbellYu-Jin LeeFred M BaikMichael C TopfEben L RosenthalMarisa E HomPublished in: Radiology. Imaging cancer (2024)
In patients with head and neck cancer (HNC), surgical removal of cancerous tissue presents the best overall survival rate. However, failure to obtain negative margins during resection has remained a steady concern over the past 3 decades. The need for improved tumor removal and margin assessment presents an ongoing concern for the field. While near-infrared agents have long been used in imaging, investigation of these agents for use in HNC imaging has dramatically expanded in the past decade. Targeted tracers for use in primary and metastatic lymph node detection are of particular interest, with panitumumab-IRDye800 as a major candidate in current studies. This review aims to provide an overview of intraoperative near-infrared fluorescence-guided surgery techniques used in the clinical detection of malignant tissue and sentinel lymph nodes in HNC, highlighting current applications, limitations, and future directions for use of this technology within the field. Keywords: Molecular Imaging-Cancer, Fluorescence © RSNA, 2024.
Keyphrases
- lymph node
- minimally invasive
- loop mediated isothermal amplification
- sentinel lymph node
- single molecule
- neoadjuvant chemotherapy
- high resolution
- coronary artery bypass
- squamous cell carcinoma
- small cell lung cancer
- real time pcr
- label free
- energy transfer
- patients undergoing
- early stage
- drug delivery
- young adults
- photodynamic therapy
- free survival
- rectal cancer