Three-dimensional histology reveals dissociable human hippocampal long-axis gradients of Alzheimer's pathology.
Diana Ortega-CruzKimberly S BressHarshvardhan GazulaAlberto RabanoJuan Eugenio IglesiasBryan A StrangePublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Path2MR enables three-dimensional (3D) brain reconstruction from blockface dissection photographs. This pipeline does not require dense specimen sampling or a subject-specific magnetic resonance (MR) image. Anatomically consistent mapping of hippocampal sections was obtained with Path2MR. Our analyses revealed an anterior-posterior gradient of hippocampal tau pathology. In contrast, the peak of amyloid-beta (Aβ) deposition was closer to the hippocampal body.
Keyphrases
- magnetic resonance
- contrast enhanced
- cerebral ischemia
- temporal lobe epilepsy
- endothelial cells
- magnetic resonance imaging
- deep learning
- subarachnoid hemorrhage
- computed tomography
- cognitive decline
- high resolution
- single cell
- machine learning
- blood brain barrier
- multiple sclerosis
- mild cognitive impairment
- high density