GDF15 regulated by HDAC2 exerts suppressive effects on oxygen-glucose deprivation/reoxygenation-induced neuronal cell pyroptosis via the NLRP3 inflammasome.

Hua Xiao Wei Chen Darong Lu Guixin Shi Xiangping Xia Shengtao Yao

Published in: Toxicology research (2024)

Our data demonstrates that GDF15 attenuates OGD/R-induced pyroptosis through NLRP3 inflammasome. HDAC2 is involved in mediating OGD-induced GDF15 down-regulation via H3K27ac modification. GDF15 overexpression and HDAC2 inhibition hold potential as useful therapeutic strategies for neuroprotection.

Keyphrases

nlrp inflammasome
high glucose
diabetic rats
histone deacetylase
type diabetes
single cell
stem cells
blood pressure
metabolic syndrome
machine learning
transcription factor
adipose tissue
bone marrow
blood glucose
subarachnoid hemorrhage