A conformational tweak for enhanced cellular internalization, photobleaching resistance and prolonged imaging efficacy.

Niranjan MeherAnil Parsram BidkarDebasish BarmanSiddhartha Sankar Ghosh Parameswar Krishnan Iyer

Published in: Chemical communications (Cambridge, England) (2021)

A strategy of conformational tweaking regulates the condensed state behavior of naphthalimide skeletal isomers (NSIs) and enhances their photophysical properties, cellular uptake and prolonged imaging capability. This salient approach results in a large Stokes shift (>120 nm), rapid cellular internalization, photobleaching resistance, and efficient bioimaging of the ribbon-like nano-assembly superior to that of its electronically similar micro-flower isomer.

Keyphrases

fluorescent probe
high resolution
molecular dynamics
molecular dynamics simulations
single molecule
living cells
photodynamic therapy
quantum dots
mass spectrometry