RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.

Tiago Henrique Zaninelli Victor Fattori Telma Saraiva-Santos Stephanie Badaro-Garcia Larissa Staurengo-Ferrari Ketlem C Andrade Nayara A Artero Camila Rodrigues Ferraz Mariana M Bertozzi Fernanda S Rasquel-Oliveira Marilia F Manchope Flávio Almeida Amaral Mauro Martins Texeira Sergio Marques Borghi Michael S Rogers Rúbia Casagrande Waldiceu Aparecido Verri

Published in: British journal of pharmacology (2022)

This study reveals a hitherto unknown neuro-immune axis in gouty arthritis that is targeted by RvD1.

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