Modulation of the activated protein C pathway in severe haemophilia A patients: The effects of thrombomodulin and a factor V-stabilizing fab.

Donald F BrophyE J MartinB M MohammedJ C BarrettJ G KuhnM E NolteB WiinbergH L HolmbergJ LundR SalboE K Waters

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2017)

The FV-stabilizing Fab resulted in enhanced CT and TGA parameters consistent with FVIII levels of 3- and 10%. Additional studies need to further characterize how modulating the APC pathway may prove beneficial in developing new haemophilia drug targets.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
computed tomography
magnetic resonance imaging
patient reported outcomes
emergency department
image quality
contrast enhanced
recombinant human