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A multi-targeting bionanomatrix coating to reduce capsular contracture development on silicone implants.

Patrick HwangChung Min ShinJennifer A SherwoodDongHo KimVineeth M VijayanKrishna C JosyulaReid C MillicanDonald HoBrigitta C BrottVinoy ThomasChul Hee ChoiSang-Ha OhDong Woon KimHo-Wook Jun
Published in: Biomaterials research (2023)
In conclusion, the bionanomatrix coating significantly reduced capsular contracture formation and promoted healing process on silicone implants by reducing myfibroblast differentiation, fibrotic tissue formation, and inflammation. A multi-targeting nitric oxide releasing bionanomatrix coating for silicone implant can reduce capsular contracture and improve healing process. The bionanomatrix coating reduces capsule thickness, α-smooth muscle actin and collagen synthesis, and myofibroblast differentiation through inhibition of TGF-β/SMADs signaling cascades in the subcutaneous mouse models for a month.
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