Overexpression of an Immune Checkpoint (CD155) in Breast Cancer Associated with Prognostic Significance and Exhausted Tumor-Infiltrating Lymphocytes: A Cohort Study.

Yu-Chen Li Quan Zhou Qing-Kun SongRui-Bin WangShuzhen LyuXiudong GuanYan-Jie ZhaoJiang-Ping Wu

Published in: Journal of immunology research (2020)

Overexpression of CD155 was correlated with more proliferative cancer cells and a dysfunctional immune microenvironment. CD155 overexpression introduced a worse relapse-free and overall survival and might be a potential immunotherapy target for breast cancer.

Keyphrases

cell proliferation
transcription factor
nk cells
stem cells
free survival
risk assessment
breast cancer risk