Deficiency of Trex1 leads to spontaneous development of type 1 diabetes.

Jiang-Man ZhaoZhi-Hui SuQiu-Ying HanMiao WangXin LiuJing LiShao-Yi HuangJing ChenXiao-Wei LiXia-Ying ChenZeng-Lin GuoShuai JiangJie PanTao LiWen XueTao Zhou

Published in: Nutrition & metabolism (2024)

Our study links the DNA-induced chronic inflammation to the pathogenesis of type 1 diabetes, and also provides an animal model for type 1 diabetes studies.

Keyphrases

type diabetes
oxidative stress
cardiovascular disease
high glucose
drug induced
circulating tumor
single molecule
cell free
insulin resistance
metabolic syndrome
adipose tissue
case control
endothelial cells
skeletal muscle
circulating tumor cells