Generation and characterization of a novel transgenic mouse harboring conditional nuclear factor-kappa B/RelA knockout alleles.

Talha IjazMaki WakamiyaHong SunAdrian RecinosRonald G TiltonAllan R Brasier

Published in: BMC developmental biology (2016)

Based on our collective data, we conclude that this novel RelACKO/CKO mouse allows for efficient deletion of RelA in a tissue-specific manner. This RelACKO/CKO mouse will be an invaluable tool for deciphering the mechanistic roles of RelA in various cells and tissues during development and in disease.

Keyphrases

nuclear factor
toll like receptor
induced apoptosis
cell cycle arrest
electronic health record
immune response
cell proliferation
signaling pathway
artificial intelligence