Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling.

Wenjuan WangYanhui ZhuZhenyu SunChen JinXiang Wang

Published in: Arthritis research & therapy (2021)

Taken together, our study revealed positive feedback regulation between USP15 and ERK2, which played a critical role in TGF-β/SMAD2 signaling to inhibit OA progression. Therefore, this specific mechanism can guide the clinical treatment of OA.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
signaling pathway
knee osteoarthritis
cell proliferation
pi k akt
rheumatoid arthritis
single cell
combination therapy