Cystic fibrosis-related diabetes develops from a combination of insulin secretion defects and insulin resistance.
Marie-Ève BolducKathryn J PotterMaxime OlmosAnne BonhoureAdèle CoriatiLaure Alexandre-HeymannFrançois TremblayAnnick LavoieMaité CarricartPeter A SeniorValérie BoudreauRemi Rabasa-LhoretPublished in: Diabetes, obesity & metabolism (2024)
Insulin resistance is correlated with glucose homeostasis and the risk of progression to CFRD. Patients combining low insulin secretion and high insulin resistance had the greatest odds of developing CFRD over a 15-year period.
Keyphrases
- insulin resistance
- type diabetes
- adipose tissue
- cystic fibrosis
- high fat diet
- metabolic syndrome
- end stage renal disease
- polycystic ovary syndrome
- skeletal muscle
- glycemic control
- high fat diet induced
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cardiovascular disease
- pseudomonas aeruginosa
- prognostic factors
- patient reported outcomes
- lung function
- blood pressure
- patient reported