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Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern uganda by high-resolution melt analysis.

Kennedy KassazaAnna C LongJennifer M McDanielsMharlove AndreWasswa FredricksonDan NyehanganePatrick OrikirizaDarwin J OperarioJoel BaziraJuliet A Mwanga-AmumpaireChristopher C MooreJennifer L GulerYap Boum
Published in: Malaria journal (2021)
The HRM-based method exhibits the flexibility required to conduct reliable assessment of resistance alleles from various sample types generated during the clinical management of malaria. Large regional variations in CQ resistance haplotypes across Southwestern Uganda emphasizes the need for continued local parasite genotype assessment to inform anti-malarial treatment policies.
Keyphrases
  • plasmodium falciparum
  • high resolution
  • public health
  • combination therapy
  • high speed
  • tandem mass spectrometry