Cell based dATP delivery as a therapy for chronic heart failure.

Ketaki N MhatreJulie MathieuAmy MartinsonGalina FlintLeslie P BlakleyArash TabeshHans ReineckeXiulan YangXuan GuanEesha MuraliJordan M KlaimanGuy L OdomMary Beth BrownRong TianStephen D HauschkaDaniel RafteryFarid Mousavi-HaramiMichael RegnierCharles E Murry

Published in: bioRxiv : the preprint server for biology (2023)

Transplanting gene-edited dATP-donor cardiomyocytes in chronically infarcted heart restores their cardiac function, improving both exercise tolerance and survival.

Keyphrases

crispr cas
single cell
heart failure
high intensity
cell therapy
copy number
physical activity
ejection fraction
genome wide
resistance training
free survival
atrial fibrillation
gene expression
high glucose
endothelial cells